Erythema multiforme is a skin condition often associated with an overreaction to an infection (usually herpes simplex) or medication. It can affect skin throughout the body. Erythema multiforme has 2 forms:
- Erythema multiforme minor—most common, is generally mild and may go away on its own, and usually caused by a virus
- Erythema multiforme major—rare, usually more severe, less likely go away on its own, and usually caused by medications
Erythema multiforme is an overreaction of the immune system to a certain trigger. Some erythema multiforme is associated with an infection or certain medications, though the exact trigger may not be known half the time. It is not clear why some people have this reaction.
Erythema multiforme is more common in young adults.
Factors that may increase your chance of getting erythema multiforme include:
- History of erythema multiforme
Infection or history of infection caused by:
- Virus—herpes infection is the main cause in erythema multiforme minor
Certain medications (usual cause of erythema multiforme major), such as:
- Non-steroidal anti-inflammatory drugs
Certain vaccinations including:
- Diptheria and tetanus vaccine
- Hepatitis B vaccine
- Smallpox vaccine
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Symptoms can vary from mild to severe. Both erythema multiforme minor and major cause skin lesions that:
- Are itchy or burning
- Typically develop over 3-4 days, but at different times. Lesions will look different in various places of the body.
- Often start on hands and feet and spread to legs, arm, and face
- Start out as small, red areas, and grow to circular, raised areas. The middle is often a dark red which fades to a pale pink and is surrounded by a bright red edge. The different colors make the lesions look like mini targets.
- May have a blister or crust in the center
- Appears equally on both sides of the body
- May develop in one mucus membrane such as the lips, inside the mouth, or the eyes
Erythema multiforme major may also cause:
- General ill feeling, fever, and achy joints before the rash appears
- More extensive rash
- Lesions that develop in 2 or more mucus membranes such as the lips, inside the mouth, or the eyes
You will be asked about your symptoms and medical history. A physical exam will be done. You may be referred to a doctor who specializes in skin problems (dermatologist).
Most cases can be diagnosed based on your medical history and skin exam. The target lesions are usually a key for diagnosis. However, the skin lesions may not be typical and a sample of the skin may be taken. The skin sample is examined under a microscope to look for findings of erythema multiforme.
Erythema multiforme will usually go away on its own in 4-6 weeks. Mild forms usually will not need treatment.
Treatment may be needed to treat an underlying infection. This may include antiviral, antibiotic, or antifungal medications. If the erythema multiforme is related to a current medication, your doctor will work with you to stop the medication and find a replacement if needed.
Severe lesion due to erythema multiforme major may also require:
- Treatment to prevent infections of the lesions
- Hospitalization for hydration if mouth lesions are severe
Management of Symptoms
Moist compresses and medications may help relieve discomfort from lesions. Medication options may include:
- Oral antihistamines to help control itching
- Topical steroid creams to help discomfort and itching
to reduce pain and fever
- Medicated mouthwash for lesions in the mouth
If the lesions were due to the herpes simplex virus, there are ways to prevent outbreaks:
- Talk to your doctor about a daily prescription of an oral antiviral medication.
- Apply sunscreen and zinc sulfate solution to the site of the herpes simplex to help prevent relapse.
American Academy of Dermatology
Family Doctor—American Family Physician
Canadian Dermatology Association
Erythema multiforme. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated April 2, 2014. Accessed August 7, 2015.
Erythema multiforme. New Zealand Dermatological Society website. Available at:
http://www.dermnetnz.org/reactions/erythema-multiforme.html. Updated December 24, 2014. Accessed August 7, 2015.