Health Library

Hypoparathyroidism

Definition

The parathyroid glands are four pea-sized glands. They are located next to the thyroid gland in the neck. The glands secrete the parathyroid hormone (PTH). PTH helps to regulate the level of calcium in the blood.

In hypoparathyroidism, there is not enough PTH secreted. This causes low levels of calcium in the blood. Low blood calcium is known as hypocalcemia.

Thyroid and Parathyroid Glands: Posterior (Back) View
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Causes

Hypoparathyroidism may be caused by:

  • Removal of the parathyroid glands
  • Damage to the parathyroid glands
  • Underlying autoimmune disorders
  • Absence of the parathyroid glands at birth
  • Genetics conditions, such as 22q11.2 deletion syndrome
  • Magnesium deficiency due to alcohol use disorder and/or malnutrition
  • Other causes, such as metal overload from iron, magnesium, or aluminium

In some cases, a cause cannot be found.

Risk Factors

Factors that may increase your chance of hypoparathyroidism include:

  • Multiple autoimmune disorders
  • Thyroid or parathyroid surgery
  • Family history of hypoparathyroidism

Symptoms

Hypoparathyroidism does not always cause symptoms. If symptoms do develop, they may include:

  • Tingling around the mouth, fingers, and toes
  • Weakness
  • Muscle cramps or twitching
  • Abnormal heart rhythm
  • Excessive nervousness or anxiety
  • Difficulty with breathing due to spasm of breathing tubes
  • Mood swings
  • Loss of memory and confusion
  • Blurred vision due to cataracts
  • Thin, brittle nails
  • Dry and scaly skin
  • Seizures

Diagnosis

You will be asked about your symptoms and medical history. A physical exam will be done.

Your bodily fluids may be tested. This can be done with:

  • Blood tests
  • Urine test

An electrocardiogram will be done to look for an abnormal heart beat.

Treatment

Treatment options include the following:

Calcium and Vitamin D Supplementation

Calcium and vitamin D will usually be taken indefinitely. They are often taken by mouth.

Calcium may be given by injection. This is done when immediate symptom relief is needed.

Parathyroid Hormone Replacement

Recombinant human parathyroid hormon is FDA approved for treatment.

May be given to patients that have high blood and urine calcium on the usual treatment.

Prevention

There are no current guidelines to prevent hypoparathyroidism.

Some surgeons may move the parathyroid glands (autotransplant) before a total thyroidectomy to prevent damage.

Resources

Hypoparathyroidism Association, Inc.
https://www.hypopara.org

National Organization for Rare Disorders
http://www.rarediseases.org

Canadian Resources

Canadian Society of Endocrinology & Metabolism
http://www.endo-metab.ca

Health Canada
http://www.hc-sc.gc.ca

References

Definition of hypoparathyroidism and related disorders. The Hypoparathyroidism Association website. Available at: https://www.hypopara.org/about-hpth/definition.html. Accessed August 23, 2017.

Hypoparathyroidism. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T114796/Hypoparathyroidism. Updated June 27, 2017. Accessed August 23, 2017.

Hypoparathyroidism. National Organization for Rare Disorders website. Available at: http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/703/viewFullReport. Updated April 2, 2014. Accessed August 23, 2017.

De Sanctis V, Soliman A, Fiscina B. Hypoparathyroidism: from diagnosis to treatment. Curr Opin Endocrinol Diabetes Obes. 2012 Dec;19(6):435-42.

Shoback D. Hypoparathyroidism. N Engl J Med 2008; 359:391-403.

Moffett JM, Suliburk J. Parathyroid autotransplantation. Endocr Pract. 2011;17 Suppl 1:83-89.

Thakker RV. Genetic developments in hypoparathyroidism. Lancet. 2001;357(9261):974-976.