Complex Regional Pain Syndrome
Complex regional pain syndrome (CRPS) refers to a chronic condition that affects the nerves and blood vessels of 1 or more limbs.
There are 2 types of CRPS:
- CRPS 1, previously called reflex sympathetic dystrophy or RSD, has no distinct nerve damage. This is the most common type of CRPS.
- CRPS 2, previously called causalgia, produces similar symptoms after a nerve injury has occurred.
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The cause of CRPS is not known. The condition likely results from several factors. It may involve overactivity of the sympathetic nervous system. Inflammation may also play a role in the disorder.
Factors that may increase your risk of CRPS include:
- Limb immobilization
- Longer than normal healing time
- The use of certain medications, such as ACE inhibitors
Symptoms usually appear after an injury. The most important symptom of CPRS is prolonged pain that may be constant or severe. Pain is typically described as burning, throbbing, aching, squeezing, or shooting.
Symptoms of CRPS change over time and may include:
- Sensitivity to touch or even a light breeze
- Swelling in the arm or leg
- Unusual sweating patterns
- Excessively warm or cool
- Hair and nails that become brittle and crack
- Abnormal movement in the arm or leg, such as a tremor, jerking, or spasms
- A pale, blue, and/or shiny look to the skin
- Limited joint movement
You will be asked about your symptoms and medical history. A physical exam will be done. You may be referred to a pain specialist.
Images may be taken of your bodily structures. This can be done with:
The electrical activity in your nerves and muscles may need to be tested. This can be done with:
You may need to have your body's heat measured. This can be done with a thermogram.
You may need to have your autonomic nervous system evaluated. This can be done with quantitative sudomotor axon reflex test (QSART), resting sweat output (RSO), or the resting skin temperature (RST).
Treatment aims to relieve pain and improve function. Early therapy may lead to better outcomes. In some cases, the condition goes away on its own; this is more common in children. Talk with your doctor about the best treatment plan for you. Options include:
Physical and Occupational Therapy
Physical and occupational therapy may help reduce pain and increase mobility.
Long-term pain often leads to
. Counseling is often required to help patients deal with chronic pain and loss of function.
Cognitive behavioral therapy may help you manage pain. It is a form of talk therapy that focuses on how the way you think affects the way you feel and act.
Your doctor may advise the following medications:
- Pain relievers
- Topical pain relievers that are applied to the skin
- Antiseizure medications
A surgical procedure called sympathectomy can permanently destroy sympathetic nerves. In some cases however, surgery may worsen symptoms.
A device may be implanted in your spine. It will deliver electric stimulus to your spinal cord to manage pain.
There are no known ways to prevent CRPS.
International Research Foundation for RSD/CRPS
Reflex Sympathetic Dystrophy Syndrome Association
Complex regional pain syndrome (CRPS). EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated April 11, 2016. Accessed June 20, 2016.
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http://www.ninds.nih.gov/disorders/reflex%5Fsympathetic%5Fdystrophy/detail%5Freflex%5Fsympathetic%5Fdystrophy.htm. Updated November 3, 2015. Accessed June 20, 2016.
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Clinical Journal of Pain. 2006;22:415-419.
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