Health Library

Perilla frutescens

Introduction

Perilla frutescens is an herb in the mint family. The leaves and seeds have been used to slow damage to cells. Perilla frutescens has also been used to help digestion and ease allergy symptoms. It can be taken as a pill, powder, or extract. Perilla frutescens can also be used as an oil or made into a tea.

Dosages

There are no advised doses for perilla frutescens

What Research Shows

May Be Effective

  • Allergic rhinitis—may ease symptoms A1

Not Enough Data to Assess

  • Allergic rhinoconjunctivitis B1
  • Gastrointestinal pain C1

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take perilla frutescens in small doses for a short time, but allergic reaction may happen in some people. D1 Not enough studies have been done to say whether it is safe to use for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.

Interactions

Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

References

REFA
Allergic Rhinitis

REFA1
Guo R, Pittler MH, et al. Herbal medicines for the treatment of allergic rhinitis: a systematic review. Ann Allergy Asthma Immunol. 2007 Dec;99(6):483-495.

REFB
Allergic Rhinoconjunctivitis

REFB1
Takano H, Osakabe N, et al. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp Biol Med (Maywood). 2004 Mar;229(3):247-254.

REFC
Gastrointestinal Pain

REFC1
Buchwald-Werner S, Fuji H, et al. Perilla extract improves gastrointestinal discomfort in a randomized placebo controlled double blind human pilot study. BMC Complement Altern Med. 2014;14:173.

REFD
Safety

REFD1
Yu H, Qiu JF, et al. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol. 2017 Oct;108(Pt B):375-391.

  • EBSCO NAT Review Board
  • 202206