Health Library

Glycine

Supplement Forms/Alternate Names:

  • L-glycine

Introduction

Glycine is a protein that is needed for brain function. It has been used to enhance mental function, lower blood pressure, and control blood glucose. Glycine can be taken as a pill or powder. It can also be applied to the skin as a cream.

Dosages

3 to 15 grams daily

What Research Shows

May Be Effective

Not Enough Data to Assess

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Editorial process and description of evidence categories can be found at EBSCO NAT Editorial Process.

Safety Notes

It is likely safe to take glycine in small doses for a short time. Not enough studies have been done to say whether it is safe to take for a long period. It is also not known whether it is safe to take by women who are pregnant or breastfeeding.

Interactions

Talk to your doctor about any supplements or therapy you would like to use. Some can interfere with treatment or make conditions worse.

References

REFA
Diabetes

REFA1
Guasch-Ferré M, Hruby A, et al. Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis. Diabetes Care. 2016 May;39(5):833-846.

REFB
Metabolic Syndrome

REFB1
Díaz-Flores M, Cruz M, et al. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Can J Physiol Pharmacol. 2013;91(10):855-860.

REFC
Psychotic Disorders

REFC1
Hoenders HJR, Bartels-Velthuis AA, et al. Natural Medicines for Psychotic Disorders: A Systematic Review. J Nerv Ment Dis. 2018 Feb;206(2):81-101.

  • EBSCO NAT Review Board Eric Hurwitz, DC
  • 202002
  • 20200527